Loren G Fong Selected Research

Progeria (Hutchinson Gilford Syndrome)

1/2021	Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome.
1/2018	Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome.
4/2016	Modulation of LMNA splicing as a strategy to treat prelamin A diseases.
5/2015	Mice that express farnesylated versions of prelamin A in neurons develop achalasia.
8/2014	Nuclear lamins and neurobiology.
3/2014	New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome.
6/2013	Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.
5/2013	Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration.
2/2013	Targeting protein prenylation in progeria.
2/2012	Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.

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Loren G Fong Research Topics

Disease

33	Progeria (Hutchinson Gilford Syndrome) 01/2021 - 12/2004
8	Hypertriglyceridemia 01/2019 - 06/2009
7	Lipodystrophy 09/2016 - 04/2008
5	Rupture 01/2021 - 10/2018
5	Cardiomyopathies (Cardiomyopathy) 08/2014 - 07/2009
4	Atherosclerosis 12/2020 - 02/2006
4	Blister (Bulla) 10/2018 - 09/2006
4	Neoplasms (Cancer) 12/2014 - 04/2010
4	Muscular Dystrophies (Muscular Dystrophy) 08/2014 - 07/2009
3	Obesity 11/2018 - 11/2011
3	Premature Aging 10/2018 - 10/2008
2	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 11/2017 - 02/2016
2	Inborn Genetic Diseases (Disease, Hereditary) 05/2015 - 09/2011
2	Coronary Disease (Coronary Heart Disease) 07/2014 - 07/2008
2	Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy) 07/2007 - 09/2006
1	Pancreatitis 03/2020
1	Glioma (Gliomas) 01/2019
1	Dystonia (Limb Dystonia) 01/2019
1	Atherosclerotic Plaque (Atheroma) 01/2019
1	Dystonia musculorum deformans type 1 01/2019
1	Movement Disorders (Movement Disorder) 01/2019
1	Insulin Resistance 11/2018
1	Autoimmune Diseases (Autoimmune Disease) 07/2017
1	Vascular Diseases (Vascular Disease) 01/2017
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2017
1	Familial Partial Lipodystrophy (Dunnigan Syndrome) 09/2016
1	Esophageal Achalasia (Megaesophagus) 05/2015
1	Neoplastic Cell Transformation 12/2014
1	Colonic Neoplasms (Colon Cancer) 12/2014
1	Ichthyosis (Xeroderma) 12/2014
1	Carcinogenesis 12/2014
1	Hyperlipoproteinemia Type I (Lipoprotein Lipase Deficiency, Familial) 07/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2014
1	Metabolic Diseases (Metabolic Disease) 07/2013
1	Bone Fractures (Bone Fracture) 06/2013
1	Body Weight (Weight, Body) 06/2013
1	Demyelinating Diseases (Demyelinating Disease) 02/2013
1	Leukoencephalopathies 02/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 02/2013
1	Majeed syndrome 09/2012
1	Inflammation (Inflammations) 09/2012
1	Hyperbilirubinemia 01/2012
1	Aneuploidy (Aneuploid) 03/2011
1	Lissencephaly 03/2010
1	Laminopathies 07/2009
1	Rare Diseases (Rare Disease) 10/2008

Drug/Important Bio-Agent (IBA)

30	prelamin AIBA 10/2018 - 12/2004
13	LaminsIBA 01/2021 - 09/2006
12	Lamin Type A (Lamin A)IBA 10/2018 - 12/2004
9	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2006
9	Triglycerides (Triacylglycerol)IBA 03/2020 - 03/2008
8	lamin CIBA 09/2016 - 07/2005
7	Lamin Type B (Lamin B)IBA 01/2021 - 03/2010
6	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 02/2013 - 07/2005
5	Lipoproteins (Lipoprotein)IBA 01/2019 - 03/2008
5	LipidsIBA 01/2019 - 01/2009
4	CholesterolIBA 12/2020 - 03/2008
3	ChromatinIBA 01/2021 - 03/2011
3	AutoantibodiesIBA 03/2020 - 01/2017
3	high density lipoprotein binding proteinIBA 01/2017 - 11/2011
3	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 01/2017 - 11/2011
2	CytokinesIBA 11/2018 - 12/2014
2	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2017 - 07/2014
2	MicroRNAs (MicroRNA)IBA 12/2014 - 08/2014
2	SphingolipidsIBA 12/2014 - 09/2012
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2014 - 09/2012
2	lipineIBA 07/2013 - 09/2012
2	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 01/2012 - 04/2010
2	EnzymesIBA 04/2010 - 03/2006
2	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2008 - 08/2006
1	Small Interfering RNA (siRNA)IBA 01/2021
1	SiliconIBA 12/2019
1	AAA ProteinsIBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	Interleukin-10 (Interleukin 10)IBA 11/2018
1	Interleukin-10 ReceptorsIBA 11/2018
1	Antinuclear AntibodiesIBA 07/2017
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	Monoclonal AntibodiesIBA 09/2016
1	Lopinavir FDA Link 09/2016
1	AntibodiesIBA 09/2016
1	Nonsense Codon (Nonsense Mutation)IBA 02/2016
1	Sphingosine-1-Phosphate ReceptorsIBA 12/2014
1	sphingosine 1-phosphate lyase (aldolase)IBA 12/2014
1	LyasesIBA 12/2014
1	Serine (L-Serine)FDA Link 07/2014
1	Cysteine (L-Cysteine)FDA Link 07/2014
1	Amino Acids FDA Link 07/2014
1	protein-S-isoprenylcysteine O-methyltransferaseIBA 06/2013
1	lonafarnib (SCH 66336)IBA 02/2013
1	Transaminases (Aminotransferases)IBA 01/2012
1	ArrestinIBA 11/2011
1	RNA Splice SitesIBA 07/2009
1	Antisense OligonucleotidesIBA 07/2009
1	LDL CholesterolIBA 07/2008
1	LDL Receptors (LDL Receptor)IBA 07/2008

Therapy/Procedure

1	Oral Administration 12/2014
1	Therapeutics 07/2009